The African Centre for Gene Technologies (ACGT) is an initiative that involves the ARC (Agricultural Research Council), CSIR (Council for Scientific and Industrial Research) and the Universities of Johannesburg, Pretoria and the Witwatersrand. The aim is to create a collaborative network of excellence in advanced biotechnology, with specific focus on the “-omics”.

Scientists create genetically modified malaria-blocking mosquitoes November 2015 - Using a groundbreaking gene editing technique, scientists have created a strain of mosquitoes capable of rapidly introducing malaria-blocking genes into a mosquito population through its progeny, ultimately eliminating the insects’ ability to transmit the disease to humans. This new model represents a notable advance in the effort to establish an antimalarial mosquito population, which with further development could help eradicate a disease that sickens millions worldwide each year. For full article, please click on the following link: Science Daily

UP students compete in international synthetic biology competition October 2015 - 2015 marks the first year that a student team from the University of Pretoria (UP) participated in the International Genetically Engineered Machines (iGEM) competition and only the third time that an African team participated in this prestigious event. The International Genetically Engineered Machines (iGEM) competition which started at the Massachusetts Institute of Technology (MIT) annually draws hundreds of high school and university teams from around the world to compete in what has become the premier international synthetic biology student competition. Synthetic biology is an emerging field that combines modern molecular biology and systems engineering concepts to develop innovative solutions, such as cancer-targeting viruses, novel biosensors, or even DIY biological 3D printers. The Forest Molecular Genetics (FMG) Programme, with support from the Department of Science and Technology (DST), sponsored seven undergraduate and one BSc Honours student to participate in the iGEM 2015 competition. The team (Pretoria_UP) was mentored by Dr Steven Hussey and additionally advised by Prof Zander Myburg and Dr Eshchar Mizrachi from the Department of Genetics and Forestry and Agricultural Biotechnology Institute (FABI) at UP. Pretoria_UP team representatives, Mr Gert Pietersen and Ms Nomakula Zim won a bronze medal at the 2015 iGEM Giant Jamboree in Boston, MA (24-28 September) where they presented their “Switch-coli” project to an international audience. They gained valuable insight into the iGEM organisation, which they will share with the rest of the team in preparation for the 2016 competition where the team aims to make their mark. The team used DNA BioBricks, the standard parts of synthetic biology, to design a genetic ...

Tree doctors from UP call for global strategy for forest health and biosecurity September 2015 - Forests worldwide are continually under threat from introduced insects and pathogens despite the best biosecurity efforts. Without a concerted global effort to understand and control invasive pests the problem is expected to worsen as international trade increases. In a review article, published in the prominent journal Science, Prof Mike Wingfield and his co-authors from the Forestry and Biodiversity Institute (FABI) at the University of Pretoria (UP) assert that an integrated global strategy is urgently needed to protect our forests. Profs Wingfield, Bernard Slippers, Brenda Wingfield from FABI and Dr Eckehard Brockerhoff, Principal Scientist at Scion in New Zealand, considers the urgent need for a global strategy to keep planted forests healthy. They reflect on the global value of plantation forests that are seriously threatened by invasive pathogens and insect pests. Globalisation is compounding this issue, and while there are solutions – including biosecurity, biological control, breeding, genetic engineering, environmentally safe chemical control and more – to protect forests, the lack of investment, capacity, and coordination of global efforts are barriers. ‘More and more pests are emerging. Their impact is a growing concern as one in every six people rely on forests for food globally, and many more depend on them for climate regulation, carbon storage, health (through improved water and air quality) as well as the wood and wood-product industries,’ explained Prof Wingfield. In South Africa, forestry contributes around R45 billion a year to the economy. ‘Keeping invasive pests out of forests should be a top priority for all countries,’ he said. The authors added that global biosecurity is only ...

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