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The African Centre for Gene Technologies (ACGT) is an initiative that involves the ARC (Agricultural Research Council), CSIR (Council for Scientific and Industrial Research) and the Universities of Johannesburg, Pretoria and the Witwatersrand. The aim is to create a collaborative network of excellence in advanced biotechnology, with specific focus on the “-omics”.

ACGT Plant Biotechnology Research Infrastructure Exhibition day December 2015 - The ACGT had its first Plant Biotechnology Research Infrastructure Exhibition day on the 12th of November 2016. This event took place at the University of Pretoria’s Plant Science Complex and was attended by 20 students, lecturers and researchers from all the ACGT partner institutions. The ACGT usually has two Plant Biotechnology Forums per year but this year only one plant forum was held at the beginning of the year and the exhibition day replaced the 2nd forum for the year. The aim of this exhibition day was to afford the ACGT partner institutions the opportunity to showcase their shared equipment/facilities that cater to the plant biotechnology community. The event was informal and the attendees had the platform to interact with the facilities managers (or representatives). Attendees were provided information about the equipment and services offered as well as discussed future collaborative projects. The following partner institutions exhibited the following facilities: 1. University of Pretoria (UP): UP showcased their QuantStudioTM 12K Flex Real-Time PCR platform. This platform aims to promote large-scale quantitative real-time PCR-based functional research at UP and at a national level. 2. Council for Scientific and Industrial Research (CSIR): The CSIR exhibited their Biosciences proteomics and Biomolecule Characterisation facility. This facility applies a range of techniques (including high resolution, high mass accuracy mass spectrometry) to quantitatively characterize complex lysates as well as recombinant peptides, proteins and antibodies. 3. Agricultural Research Council (ARC): The ARC displayed their Illumina MiSeq and Illumina HiSeq2500 platforms that generate NGS datasets ranging from 125 to 300bp in size. The platform also hosts a Laser ...

Scientists create genetically modified malaria-blocking mosquitoes November 2015 - Using a groundbreaking gene editing technique, scientists have created a strain of mosquitoes capable of rapidly introducing malaria-blocking genes into a mosquito population through its progeny, ultimately eliminating the insects’ ability to transmit the disease to humans. This new model represents a notable advance in the effort to establish an antimalarial mosquito population, which with further development could help eradicate a disease that sickens millions worldwide each year. For full article, please click on the following link: Science Daily

UP students compete in international synthetic biology competition October 2015 - 2015 marks the first year that a student team from the University of Pretoria (UP) participated in the International Genetically Engineered Machines (iGEM) competition and only the third time that an African team participated in this prestigious event. The International Genetically Engineered Machines (iGEM) competition which started at the Massachusetts Institute of Technology (MIT) annually draws hundreds of high school and university teams from around the world to compete in what has become the premier international synthetic biology student competition. Synthetic biology is an emerging field that combines modern molecular biology and systems engineering concepts to develop innovative solutions, such as cancer-targeting viruses, novel biosensors, or even DIY biological 3D printers. The Forest Molecular Genetics (FMG) Programme, with support from the Department of Science and Technology (DST), sponsored seven undergraduate and one BSc Honours student to participate in the iGEM 2015 competition. The team (Pretoria_UP) was mentored by Dr Steven Hussey and additionally advised by Prof Zander Myburg and Dr Eshchar Mizrachi from the Department of Genetics and Forestry and Agricultural Biotechnology Institute (FABI) at UP. Pretoria_UP team representatives, Mr Gert Pietersen and Ms Nomakula Zim won a bronze medal at the 2015 iGEM Giant Jamboree in Boston, MA (24-28 September) where they presented their “Switch-coli” project to an international audience. They gained valuable insight into the iGEM organisation, which they will share with the rest of the team in preparation for the 2016 competition where the team aims to make their mark. The team used DNA BioBricks, the standard parts of synthetic biology, to design a genetic ...


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